Bacillus clausii PBC429™

Bacillus clausii PBC429™ is a clinically supported, spore-forming probiotic that promotes gastrointestinal health and microbial balance. Its robust spore structure ensures survival through gastric conditions and targeted activity in the intestine. Preclinical studies demonstrate excellent safety, with no observed toxicity, no adverse effects on physiological parameters, and a high safety margin (NOAEL established). In vivo efficacy studies show a significant reduction in diarrhea incidence, delayed onset, and improved stool consistency. Clinical evidence supports its role in managing acute and antibiotic-associated diarrhea, with demonstrated reduction in duration and frequency of episodes. The strain is well tolerated and suitable for use alongside antibiotic therapy. PBC429™ is an ideal choice for formulations targeting gut health, digestive balance, and immune support.