Meloff®

Meloff® is a next-generation food supplement designed to support sleep quality through a targeted neuromodulatory approach. Based on Melissa Phytosome™ (Relissa™), a standardized lemon balm extract with enhanced bioavailability, the formulation acts by modulating GABA levels through inhibition of GABA transaminase, a key mechanism involved in sleep regulation. This advanced delivery system significantly improves the absorption and activity of rosmarinic acid compared to conventional extracts, translating into a more effective physiological response. Clinical studies demonstrate that Meloff® is more effective than placebo in improving sleep quality, quality of life and insomnia severity, with no reported side effects. Notably, Meloff® has been shown to increase deep sleep (slow-wave sleep), the most restorative phase, while reducing lighter sleep stages. A high percentage of subjects reported improved sleep quality, confirming its impact on overall sleep architecture. Meloff® is the winner of the NutraIngredients Awards 2025 in the Botanicals category, further recognizing its innovation and scientific value in the sleep support segment. Meloff® represents a science-driven solution for individuals experiencing mild insomnia or poor sleep quality who are seeking an effective, non-pharmacological approach.